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NITRIC OXIDE
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DeCS
Descriptor
English
:
Nitric Oxide
Descriptor
Spanish
:
Óxido Nítrico
Descriptor
Portuguese
:
Óxido Nítrico
Tree Number:
D01.339.387
D01.625.550.500
D01.625.700.500
D01.650.550.587.600
Definition
English
:
A free radical gas produced endogenously by a variety of mammalian
cells
, synthesized from
ARGININE
by
NITRIC OXIDE SYNTHASE
.
Nitric oxide
is one of the
ENDOTHELIUM-DEPENDENT RELAXING FACTORS
released by the vascular
endothelium
and mediates
VASODILATION
. It also inhibits
platelet aggregation
, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular
endothelium
.
Nitric oxide
activates cytosolic
GUANYLATE CYCLASE
and thus elevates intracellular levels of
CYCLIC GMP.
Pharmacological Action:
Bronchodilator Agents
Endothelium-Dependent Relaxing Factors
Free Radical Scavengers
Neurotransmitter Agents
See Related
English
:
Endothelium-Dependent Relaxing Factors
Nitric Oxide Donors
History Note
English
:
1965
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
9753
Unique Identifier:
D009569
Occurrence in VHL
:
Similar:
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